Purified Anti-Human LIN28A Antibody[14E6-4E6] (AN010440P)
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For research use only.
| Alternate Names | CSDD, ZCCHC, LIN, LIN28A, CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A |
| Clone | |
| Verified Samples | Verified Samples in FCM: NTERA-2 cells |
| Dilution | FCM ≤ 0.2 µg per million cells in 100 µL volume |
| Background | LIN28A is a highly conserved RNA-binding protein and reprogramming factor that plays important roles in development, self-renewal of stem cells, glucose metabolism and tumorigenesis. Lin28A modulates not only miRNAs, particularly the let-7 family miRNAs, but also the translation of mRNAs that are important for cell growth and metabolism. LIN28A/B has been observed to be overexpressed in a wide range of solid tumors and hematological malignancies, and has emerged as a new therapeutic target candidate for cancer. |
| Immunogen | Recombinant Human LIN28A protein |
| Abbre | LIN28A |
| Swissprot | |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Mouse IgG2a, κ |
| Applications |
FCM
|
| Research Areas | Neuroscience;Stem Cells;Developmental Biology;Epigenetics and Nuclear Signaling;Embryonic Stem Cells |
| Cellular Localization |
Cytoplasm, Endoplasmic reticulum, Nucleus
|
| Tissue Specificity |
Expressed in embryonic stem cells, placenta and testis. Tends to be up-regulated in HER2-overexpressing breast tumors.
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | Unconjugated |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
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